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HelpTest Code MPSER Mucopolysaccharides Quantitative, Serum
Ordering Guidance
This test alone is not diagnostic for a specific mucopolysaccharidosis. Follow-up testing must be performed to confirm a diagnosis.
Necessary Information
1. Patient's age is required.
2. Reason for testing is required.
3. Biochemical Genetics Patient Information (T602) is recommended. This information aids in providing a more thorough interpretation of results. Send information with specimen.
Specimen Required
Patient Preparation: Do not administer low-molecular weight heparin prior to collection.
Collection Container/Tube: Red top
Submission Container/Tube: Plastic vial
Specimen Volume: 0.5 mL
Pediatric: 0.2 mL
Collection Instructions: Centrifuge and aliquot serum into a plastic vial.
Forms
1. Biochemical Genetics Patient Information (T602)
2. If not ordering electronically, complete, print, and send a Biochemical Genetics Test Request (T798) with the specimen.
Useful For
Quantification of dermatan sulfate, heparan sulfate, and keratan sulfate in serum to support the biochemical diagnosis of mucopolysaccharidoses types I, II, III, IV, VI, or VII
Method Name
Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)
Reporting Name
Mucopolysaccharides Quant, SSpecimen Type
Serum RedSpecimen Minimum Volume
0.2 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum Red | Refrigerated (preferred) | 90 days | |
| Frozen | 90 days | ||
| Ambient | 14 days |
Reference Values
DERMATAN SULFATE
≤300.00 ng/mL
HEPARAN SULFATE
≤55.00 ng/mL
≤5 years: ≤1800.00 ng/mL
6-18 years: ≤1500.00 ng/mL
≥19 years: ≤1200.00 ng/mL
Day(s) Performed
Twice per month
Report Available
9 to 15 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Test Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
83864
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| MPSER | Mucopolysaccharides Quant, S | 93726-8 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| BG714 | Reason for Referral | 42349-1 |
| 604908 | Dermatan Sulfate | 2203-8 |
| 604909 | Heparan Sulfate | 93725-0 |
| 604910 | Total Keratan Sulfate | 93724-3 |
| 604911 | Interpretation (MPSER) | 59462-2 |
| 604907 | Reviewed By | 18771-6 |
Special Instructions
Testing Algorithm
For more information see Newborn Screening Follow up for Mucopolysaccharidosis type II