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Test Code CHIMU Chimerism Transplant No Cell Sort, Varies

Useful For

Determining the relative amounts of donor and recipient cells in a specimen

 

An indicator of bone marrow transplant success

Testing Algorithm

Complete chimerism analysis requires 3 specimens, under 3 separate orders, for the 3 separate tests listed below. These specimens should be submitted when collected. An interpretive report will be provided once all specimens are received.

 

Pre-Transplant:

-CHRGB / Chimerism-Recipient Germline (Pretransplant), Varies

-CHIDB / Chimerism-Donor, Varies

-ADONO / Additional Chimerism Donor (Bill Only), if applicable

 

Post-Transplant:

-CHIMU / Chimerism Transplant No Cell Sort, Varies or CHIMS / Chimerism Transplant Sorted Cells, Varies

 

Billing occurs with the following tests:

Pre-transplant:

-CHRGB / Chimerism-Recipient Germline (Pretransplant), Varies

-ADONO / Additional Chimerism Donor (Bill Only), if applicable

 

Post-Transplant:

-CHIMU / Chimerism Transplant No Cell Sort, Varies

-CHIMS / Chimerism Transplant Sorted Cells, Varies

-SORT1 / Chimerism Cell Sort 1 (Bill Only)

-SORT2 / Chimerism Cell Sort 2 (Bill Only)

 

For more information see Chimerism-Recipient Germline Testing Algorithm

Method Name

Polymerase Chain Reaction (PCR) Amplification/Capillary Electrophoresis

Reporting Name

Chimerism Transplant No Cell Sort

Specimen Type

Varies


Ordering Guidance


This test is for the post-bone marrow transplant evaluation of the presence of donor cells in the post-transplant recipient specimen. For post-bone marrow transplant testing to determine the relative amounts of donor and recipient cells, see CHIMS / Chimerism Transplant Sorted Cells, Varies



Additional Testing Requirements


 



Shipping Instructions


1. Specimen must arrive within 7 days of collection.

2. Collect and package specimen as close to shipping time as possible.



Necessary Information


Specimen Type is required, either as an answer to the Order Questions or on Chimerism Analysis Information (T594) if not ordering electronically. Testing will be delayed if this information is not provided.



Specimen Required


Submit only 1 of the following specimens:

 

Specimen Type: Blood

Container/Tube:

Preferred: Lavender top (EDTA)

Acceptable: Yellow top (ACD)

Specimen Volume: 4 mL

Collection Instructions:

1. Only 1 tube is required.

2. Invert several times to mix blood.

3. Label specimen as blood.

4. Send whole blood specimen in original tube. Do not aliquot.

 

Specimen Type: Bone marrow

Container/Tube:

Preferred: Lavender top (EDTA)

Acceptable: Yellow top (ACD)

Specimen Volume: 2 mL

Collection Instructions:

1. Invert several times to mix bone marrow.

2. Label specimen as bone marrow.

3. Send bone marrow specimen in original tube. Do not aliquot.


Specimen Minimum Volume

Blood: 3 mL
Bone marrow: See Specimen Required
Lesser volumes may be acceptable, depending on white cell count.
Call 800-533-1710 or 507-266-5700 with questions.

Specimen Stability Information

Specimen Type Temperature Time Special Container
Varies Ambient (preferred) 7 days PURPLE OR PINK TOP/EDTA
  Refrigerated  7 days PURPLE OR PINK TOP/EDTA

Reference Values

An interpretive report will be provided.

Report Available

4 to 8 days following receipt of Pre and Donor Specimens

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

81267-Chimerism (engraftment) analysis, post hematopoietic stem cell transplantation specimen, includes comparison to previously performed baseline analyses, without cell selection

LOINC Code Information

Test ID Test Order Name Order LOINC Value
CHIMU Chimerism Transplant No Cell Sort 34574-4

 

Result ID Test Result Name Result LOINC Value
MP026 Specimen Type 31208-2
37313 Final Diagnosis 34574-4

Forms

1. Chimerism Analysis Information Sheet (T594)

2. If not ordering electronically, complete, print, and send a Hematopathology/Cytogenetics Test Request (T726) with the specimen.

Day(s) Performed

Monday through Friday